Figure 4.

Summary of the main strategies and findings in Tauopathy zebrafish models. Upon hyperphosphorylation, Tau protein detached from the microtubules and form oligomers. Oligomer accumulation led to pre-tangles and in some cases to neurofibrillary tangles. Zebrafish transgenic lines overexpressed human Tau proteins in neurons which led to apoptosis (green cells), inflammation response with microglia activation (red cells) and locomotion defects (visual motor response profile). Transgenic lines for human Tau WT or P301L and A152T mutations, revealed that neuroprotective factors can rescue neurotoxicity as well as activation of the proteasome and autophagy pathways.