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Regulation of p53 signaling by USP15. USP15 translation is upregulated by TGF-β through the PI3K/AKT pathway, which in turn increases the stabilization of p53 by its deubiquitination and activates p53 signaling. In another way, USP15 also promotes the ubiquitin-dependent degradation of p53 by deubiquitination and enhanced stabilization of the E3 ubiquitin ligase for p53, MDM2, resulting in the downregulation of p53 target gene expression [34,84].
