Table 3.
Long non-coding RNAs involved in neuroinflammation in Parkinson’s disease. ↑ shows up-regulated, ↓ shows down-regulated.
| LncRNAs | Study Model | LncRNA Expression |
Target | Function | References |
|---|---|---|---|---|---|
| LncRNA UCA1 | 6-OHDA rat model | ↑ | PI3K/AKT | Upregulated oxidative stress and inflammation through PI3K/Akt signaling pathway | [78] |
| LncRNA HOTAIR | MPP+-SH-SY5Y cells, MPTP-mouse models | ↑ | miR-126-5p | Regulate miR-126-5p and RAB3IP to promote the progression of PD. | [79] |
| LncRNA-HOTAIR | MPP+-SH-SY5Y cell model, MPTP-mice model | ↑ | miR-205-5p-LRRK2 | Upregulated LRRK2 expression by miR-205 inhibition and induce neuronal apoptosis and neuroinflammation | [80] |
| LncRNA-MALAT1 | MPP+-SH-SY5Y cell model, MPTP-mice model | ↑ | miR-205-5p-LRRK2 | Upregulated LRRK2 expression by miR-205 inhibition and induce neuronal apoptosis and neuroinflammation | [81] |
| LncRNA-AS Uch1 | iMN9D cells, MPTP-mice model | ↓ | Nurr1 | Downregulated ASUch1 expression is regulated by downregulated Nurr1 activity, results in dopaminergic dysfunction | [82] |
| Lnc-p21 | MPP+-SH-SY5Y cells | ↑ | miR-625 | Target miR-625 to regulate TRPM2 expression that increase the levels of ROS, TNF-α, IL-1β and IL-6, and trigger cell apoptosis | [83] |
| LncRNA AL049437 | MPP+-SH-SY5Y cells, MPTP-mouse model | ↑ | miR-205-5p | Regulated the miR-205-5p/MAPK1 axis to increase the levels of inflammatory factors and ROS | [84] |
| LncRNA NEAT1 | MPP+-SH-SY5Y cells, MPTP-mouse model | ↑ | PINK1 | Inhibited the degradation of PINK1 to increase autophagy and displayed a neuroprotective role in PD | [85] |