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. 2021 May 4;21(9):3191. doi: 10.3390/s21093191

Figure 3.

Figure 3

LSPR biosensing strategies based on nanopatterned structures: (A) Detection of miRNA using an inverted ‘L’-shaped nanostructure with nanograting pattern substrates functionalized with locked nucleic acids (LNAs). Reproduced with permission from [54]; (B) Detection of human IgG using a polystyrene (PS) sphere-deposited glass slide functionalized with antibodies, in which the use of PS of different sizes or shapes results in diverse cup substrates, enabling the modulation of plasmonic response. Reproduced with permission from [50]; (C) Detection of cancer cells attached to a metal–insulator–metal (MIM) integrative PDMS substrate. Reproduced with permission from [51]; (D) Detection of sialic acid by capturing with mercaptophenyl boronic acid (MPBA) via metal-S bond on nanocone shaped polyethylene terephthalate (PET) nanostructures densely covered with Au and AgNPs. Reproduced with permission from [67]. R2R, roll-to-roll; HRP, horseradish peroxidase.