Table 5.

Common targets of SF EV miRNAs found to be significantly enriched in the joints of RA patients with high-grade inflammation.

Target Gene ID	Target Gene Name	miRNA Regulators
IGF1R	Insulin like growth factor 1 receptor	hsa-miR-143-3p hsa-miR-150-3p hsa-miR-185-5p hsa-miR-21-5p hsa-miR-223-3p hsa-miR-223-5p hsa-miR-378a-3p hsa-miR-503-5p hsa-miR-7-5p
PTEN	Phosphatase and tensin homolog	hsa-miR-103a-3p hsa-miR-106b-3p hsa-miR-142-5p hsa-miR-155-5p hsa-miR-21-3p hsa-miR-21-5p hsa-miR-25-3p
VEGFA	Vascular endothelial growth factor A	hsa-miR-101-3p hsa-miR-150-5p hsa-miR-185-5p hsa-miR-21-5p hsa-miR-378a-3p hsa-miR-503-5p
BCL2	BCL2, apoptosis regulator	hsa-miR-143-3p hsa-miR-192-5p hsa-miR-21-5p hsa-miR-503-5p hsa-miR-7-5p
FBXW7	F-box and WD repeat domain containing 7	hsa-miR-155-5p hsa-miR-223-3p hsa-miR-223-5p hsa-miR-25-3p hsa-miR-503-5p
MYB	MYB proto-oncogene, transcription factor	hsa-miR-103a-3p hsa-miR-150-3p hsa-miR-150-5p hsa-miR-155-5p hsa-miR-503-5p
EGFR	Epidermal growth factor receptor	hsa-miR-146b-5p hsa-miR-21-5p hsa-miR-27a-5p hsa-miR-7-5p
RAC1	Rac family small GTPase 1	hsa-miR-101-3p hsa-miR-142-3p hsa-miR-142-5p hsa-miR-155-5p
TP53	Tumor protein p53	hsa-miR-150-3p hsa-miR-150-5p hsa-miR-25-3p hsa-miR-28-3p
ZEB1	Zinc finger E-box binding homeobox 1	hsa-miR-101-3p hsa-miR-142-5p hsa-miR-150-5p hsa-miR-223-3p