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. 2021 May 5;22(9):4902. doi: 10.3390/ijms22094902

Figure 2.

Figure 2

A unique subset of fibroinflammatory cytokines tightly associated with reproductive and chronological aging. (A) Graphs showing relative cytokine intensities in the follicular fluid of the first follicle in women undergoing assisted reproductive technology (ART) vs. age. Fibroinflammatory markers IL-3, IL-7, IL-15, TGF-β1, TGF-β3 and MIP-1β were significantly correlated with increasing chronological age (years). (B) Graphs showing cytokine markers IL-3, IL-7, IL-15, TGF-β1, TGF-β3 and MIP-1β were also significantly negatively correlated with anti-Müllerian hormone (ng/mL) levels, an indicator for decreased ovarian reserve. The lines correspond to the fitted regression equation. * p < 0.05, ** p < 0.01.