Table 7.
The functional analysis of the upregulated genes at 12 h after LLL irradiation.
| Gene Ontology (GO) ID and Terms on Biological Process (BP) | Count | % | p-Value |
|---|---|---|---|
| GO:0007166~cell surface receptor signaling pathway | 28 | 10.73 | 2.37 × 10−2 |
| GO:0006955~immune response | 24 | 9.20 | 3.39 × 10−4 |
| GO:0006952~defense response | 23 | 8.81 | 6.37 × 10−4 |
| GO:0009605~response to external stimulus | 23 | 8.81 | 2.57 × 10−2 |
| GO:0048584~positive regulation of response to stimulus | 22 | 8.43 | 3.73 × 10−2 |
| GO:0003008~system process | 21 | 8.05 | 5.96 × 10−2 |
| GO:0002682~regulation of immune system process | 19 | 7.28 | 6.30 × 10−3 |
| GO:0050776~regulation of immune response | 18 | 6.90 | 1.70 × 10−4 |
| GO:0016192~vesicle-mediated transport | 17 | 6.51 | 5.14 × 10−2 |
| GO:0045087~innate immune response | 16 | 6.13 | 6.31 × 10−4 |
| GO:0007186~G-protein coupled receptor signaling pathway | 16 | 6.13 | 2.69 × 10−2 |
| GO:0051707~response to other organism | 15 | 5.75 | 1.72 × 10−3 |
| GO:0043207~response to external biotic stimulus | 15 | 5.75 | 1.72 × 10−3 |
| GO:0009607~response to biotic stimulus | 15 | 5.75 | 2.76 × 10−3 |
| GO:0050877~neurological system process | 15 | 5.75 | 6.02 × 10−2 |
| GO:0006897~endocytosis | 14 | 5.36 | 6.77 × 10−4 |
| GO:0002252~immune effector process | 14 | 5.36 | 1.83 × 10−3 |
| GO:0001775~cell activation | 14 | 5.36 | 1.00 × 10−2 |
| GO:0002684~positive regulation of immune system process | 14 | 5.36 | 1.51 × 10−2 |
| GO:0009617~response to bacterium | 13 | 4.98 | 3.80 × 10−4 |
| GO:0050778~positive regulation of immune response | 13 | 4.98 | 2.71 × 10−3 |
| GO:0045321~leukocyte activation | 13 | 4.98 | 5.47 × 10−3 |
| GO:0051094~positive regulation of developmental process | 13 | 4.98 | 7.29 × 10−2 |
| GO:0002768~immune response-regulating cell surface receptor signaling pathway | 12 | 4.60 | 9.96 × 10−5 |
| GO:0002764~immune response-regulating signaling pathway | 12 | 4.60 | 1.12 × 10−3 |
| GO:0046649~lymphocyte activation | 12 | 4.60 | 4.91 × 10−3 |
| GO:0002449~lymphocyte mediated immunity | 11 | 4.21 | 2.83 × 10−5 |
| GO:0002443~leukocyte mediated immunity | 11 | 4.21 | 1.79 × 10−4 |
| GO:0002250~adaptive immune response | 11 | 4.21 | 6.62 × 10−4 |
| GO:0098542~defense response to other organism | 11 | 4.21 | 2.23 × 10−3 |
| GO:0042742~defense response to bacterium | 10 | 3.83 | 9.53 × 10−5 |
| GO:0002460~adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 10 | 3.83 | 1.65 × 10−4 |
| GO:0002429~immune response-activating cell surface receptor signaling pathway | 10 | 3.83 | 1.01 × 10−3 |
| GO:0002757~immune response-activating signal transduction | 10 | 3.83 | 7.63 × 10−3 |
| GO:0002253~activation of immune response | 10 | 3.83 | 1.40 × 10−2 |
| GO:0016064~immunoglobulin mediated immune response | 9 | 3.45 | 2.44 × 10−5 |
| GO:0019724~B cell mediated immunity | 9 | 3.45 | 2.66 × 10−5 |
| GO:0042113~B cell activation | 9 | 3.45 | 3.08 × 10−4 |
| GO:0006959~humoral immune response | 9 | 3.45 | 3.25 × 10−4 |
| GO:0051251~positive regulation of lymphocyte activation | 9 | 3.45 | 8.51 × 10−4 |
| GO:0002696~positive regulation of leukocyte activation | 9 | 3.45 | 1.42 × 10−3 |
| GO:0050867~positive regulation of cell activation | 9 | 3.45 | 1.70 × 10−3 |
| GO:0051249~regulation of lymphocyte activation | 9 | 3.45 | 7.68 × 10−3 |
| GO:0002694~regulation of leukocyte activation | 9 | 3.45 | 1.59 × 10−2 |
| GO:0050865~regulation of cell activation | 9 | 3.45 | 2.28 × 10−2 |
| GO:0006958~complement activation, classical pathway | 8 | 3.07 | 5.50 × 10−6 |
| GO:0002455~humoral immune response mediated by circulating immunoglobulin | 8 | 3.07 | 1.24 × 10−5 |
| GO:0006956~complement activation | 8 | 3.07 | 1.65 × 10−5 |
| GO:0072376~protein activation cascade | 8 | 3.07 | 6.86 × 10−5 |
| GO:0006909~phagocytosis | 8 | 3.07 | 3.11 × 10−3 |
Count: genes involved in the term; percentage (%): involved genes/total genes; p-value: modified Fisher exact p-value.