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. 2021 Apr 29;22(9):4716. doi: 10.3390/ijms22094716

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HK2 regulatory pathways in healthy cells. Continuous lines indicate direct effects; dashed lines indicate indirect effects. FGF: Fibroblast Growth Factor; FGFR: Fibroblast Growth Factor Receptor; TGF-β: Transforming Growth Factor β; TβR: Transforming Growth Factor β Receptor; PI3K: PhosphoInositide-3-Kinase; mTORC: mammalian Target of Rapamycin Complex; p70S6K: p70-S6 Kinase 1; GSK-3β Glycogen Synthase Kinase 3 β; PHLPP: PH domain and Leucine rich repeat Protein Phosphatase; ΔΨ_m: mitochondrial membrane potential; mPTP: mitochondrial Permeability Transition Pore.