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. 2021 May 4;13(9):2209. doi: 10.3390/cancers13092209

Figure 2.

Figure 2

High levels of BIRC5/survivin are associated with poor survival prognosis independent of nodal and ER status. (A) Kaplan-Meier curves depict 5-year overall survival probability for patients of the VGR-BC, SCAN-B, and METABRIC cohorts. Data were split by BIRC5/survivin median levels of the protein in tumor lysates in VGR-BC and of the mRNA levels in SCAN-B and METABRIC. Graphs are shown for patients with (nodal positive, thick lines) and without (nodal negative, thin lines) BC metastases into lymph nodes. (B) Kaplan-Meier curves depict 5-year overall survival probability for the ER-positive (ER+) and ER-negative (ER−) patients within the VGR-BC, SCAN-B, and METABRIC cohort. Data were split by BIRC5/survivin median levels of the protein in tumor lysates in VGR-BC and of the mRNA levels in SCAN-B and METABRIC. High BIRC5/survivin level survival curves are shown in red and low in black. Hazard ratio was estimated separately for high- and low-level patient groups.