Table 1.
Clinical characteristics of the breast cancer cohorts.
| KERRYPNX | VGR-BC | SCAN-B | METABRIC |
|---|---|---|---|
| Total number | 845 | 3678 | 1980 |
| Years | 1989–1995 | 2010–2015 | 1963–2005 |
| Data type | Protein, ELISA normalized to total protein | mRNA, RNAseq, polyA-based cDNA library, paired-end, Illumina HiSeq 2000 | mRNA, microarray, Illumina, GPL6947, HumanHT-12 V3.0 |
| Age at diagnosis, years | 65.64 ± 14.83 | 62.74 ± 13.15 | 60.42 ± 13.03 |
| (mean ± SD, p-value vs. VGR-BC) | p = 1 × 10−8 | p = 1 × 10−20 | |
| Tumor size, mm | 30.49 ± 17.12 | 19.91 ± 12.18 | 26.22 ± 15.34 |
| (mean ± SD, p-value vs. VGR-BC) | p = 5 × 10−93 | p = 7 × 10−11 | |
| ER | 76.69% | 90.71% | 77.34% |
| positive | n = 845 | n = 3155 | n = 1498 |
| PR | 51.83% | 84.96% | 52.53% |
| positive | n = 845 | n = 3345 | n = 1980 |
| HER2 | Not available | 14.23% | 12.47% |
| positive | n = 3556 | n = 1980 | |
| LN metastases | 59.38% | 36.70% | 47.32% |
| positive | n = 581 | n = 3180 | n = 1980 |