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. 2021 Apr 28;22(9):4637. doi: 10.3390/ijms22094637

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Sequence alignment of TRPM2 and TRPM8. Sequence alignment of the membrane interfacial cavity (formed by: Pre-S1 domain and MHR4 from the adjacent subunit (green), junction between S4 and S5 (purple) and TRP domain (orange)) of hs-, dr- and nvTRPM2 and hsTRPM8. Target positions (yellow) within MHR4-PreS1 labelled mutant I (hsW743, drW718, and nvW705), S4–S5 linker labelled mutant II (hsK918, drR934, and nvR969) and TRP domain separated in mutant III (hsR1067, drR1082, nvR1104) and mutant IV (hsR1077, drR1092, nvR1114).