Figure 3.

Vasorelaxant effects of acetylcholine (A,C) and sodium nitroprusside (B,D) in the mesenteric G3 arteries (A,B) and aorta (C,D) from normotensive control (WKY) and URB597-treated (WKY + URB) rats or hypertensive (SHR) and URB597-treated (SHR + URB) rats. URB597 at 1 mg/kg or its vehicle was injected intraperitoneally every 12 h for 14 days. Vasodilatory responses are shown as percentages of the reference response of the isometric contraction induced by phenylephrine (Phe). Mean ± SEM of n = 6 tissues for each curve. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared to the * WKY, as determined by one-way ANOVA followed by Bonferroni’s multiple comparison tests. In a few cases, the SEM is smaller than or equal to the size of the symbols. See Table 1 and Table 2 for statistical analysis.