Table 3.
Calculated difference factors (f1) and similarity factors (f2) for PAX release profiles from ethanolic solution (PAX/EtOH), commercial formulation (Ebetaxel®), and TPGS-b-PCL micellar formulations. The profiles are considered similar if f1 ≤ 15 and f2 ≥ 50.
| Solution/Formulation | Difference Factor (f1) | Similarity Factor (f2) |
|---|---|---|
| PAX/EtOH vs. Ebetaxel® | 23.72 | 32.75 |
| Ebetaxel® vs. TPGS2000-b-PCL4000 | 48.45 | 24.28 |
| Ebetaxel® vs. TPGS3500-b-PCL7000 | 52.62 | 22.66 |
| Ebetaxel® vs. TPGS5000-b-PCL15000 | 77.64 | 14.81 |
| TPGS2000-b-PCL4000 vs. TPGS3500-b-PCL7000 * | 8.09 | 75.75 |
| TPGS2000-b-PCL4000 vs. TPGS5000-b-PCL15000 | 56.62 | 36.38 |
| TPGS3500-b-PCL7000 vs. TPGS5000-b-PCL15000 | 52.80 | 38.93 |
* similar release profile.