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. 2021 Apr 30;13(9):2160. doi: 10.3390/cancers13092160

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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TERT expression and telomere length relationship in HCC. (A) Protein–protein interaction (PPI) analysis of TERT using the CBS probe PINGS^TM in HCC tissues. (B) Expression profiles of the eight TERT-interacting genes from the STRING database in tumor versus adjacent non-tumor tissues. (C) Comparison of shelterin complex TRF1, TRF2, POT1, TPP1, TINP2, and RAP1 between tumor and non-tumor tissues. (D) Comparison of TERT promoter mutations, TERT expression and telomere length between tumor and non-tumor tissues. TRF, telomeric repeat-binding factors; POT1, protection of telomeres 1; TPP1, POT1-TIN2 organizing protein; TIN2, TRF1 and TRF2 interacting nuclear protein 2; RAP1, repressor/activator protein 1. NS, non-significance; *** p < 0.001.