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. 2021 Apr 28;22(9):4673. doi: 10.3390/ijms22094673

Figure 6.

Figure 6

In vivo antitumor activity of Taxol, PTX/HA-DOCA, and PTX/HA-DOCA-His micelles in a multidrug-resistant human breast carcinoma MCF-7/Adr tumor model with saline as a control group. (A) Relative tumor volume changes of different treatments with time past first injection (mean ± SE, n = 5). * p < 0.05, ** p < 0.01 (PTX/HA-DOCA-His micelles vs. other treatment). (B) Changes of body weight in mice following different treatments. (C) Measured tumor weights after excision, plotted as relative tumor weight ratio. Tumor growth inhibition rate (IR, %) was calculated as: (1- (mean tumor weight of drug treated group/mean tumor weight of saline treated group)) × 100. (D) Histological analyses of tumor tissues treated with saline, Taxol solution, PTX/HA-DOCA, and PTX/HA-DOCA-His micelles collected on day 20 using H&E staining [243].