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Antiviral activity against HSV-1 of extracts at pH 7.00. Different assays were performed in order to evaluate anti-HSV-1 activity. Extracts inhibited the early stages of infection, acting in co-treatment (A) and virus pre-treatment (C) assays. Extracts were not able to interact with the cellular surface (B) or block the viral replication (D). Statistical differences were evaluated via two-way ANOVA; a value of p ≤ 0.05 was considered significant, with * p ≤ 0.0001.
