Figure 2.

(A) Genetic variant rs1229984 (ADH1B gene), showing a significantly higher prevalence in our Hungarian psoriasis group (n = 776) compared to the Hungarian general population (n = 2967,leads to increased catalytic activity of the ADH enzyme that may alter the levels of ethanol and acetaldehyde. (B) Possible involvement of genetic variant rs1799971 (OPRM1 gene), found to increase the risk of familial psoriasis by twofold compared to sporadic cases in our Hungarian psoriasis group, in the psoriasis–itch–stress–alcohol consumption cycle.