Table 2.
Examples of various lipid compositions employed for liposome synthesis. Cationic lipids: DOTAP (1,2-dioleoyl-3-trimethylammoniun-propane); zwitterionic lipids: PC (phosphatidyl choline), DPPC (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine); neutral lipids: DOPE (1,2-dioleoylsn-glycerol-3 phosphoethanolamine), CHOL (cholesterol); anionic lipids: DSPE (1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol)).
| Lipid Composition/Synthesis Method | Drug Cargo | Active Targeting | Ref. |
|---|---|---|---|
| DOTAP:DOPE:DSPE-PEG2000/thin layer film hydration method |
5-FU | HA for CD44 receptor targeting | [118] |
| PC:CHOL:DSPE/thin layer film hydration method |
5-FU | Transferrin for transferrin receptor (TFR) targeting | [100] |
| DPPC:CHOL:DSPE-PEG2000/thin layer film hydration method |
5-FU | Folate for folate receptor (FR) targeting | [147] |
| PC:DSPE-PEG2000/ethanol injection method | rapamycin | Not applicable (NA) | [148] |
| PC-98T:DSPE-PEG2000:CHOL/thin layer film hydration method |
SN38 | HA | [149] |
| PC:DSPE-PEG2000/thin layer film hydration method | OXP | NA | [150] |