Table 2.
Baseline and follow-up coagulation parameters of hospitalized patients with COVID-19.
| Normal Cytokines Levels | Increased Cytokines Levels | Total | Reference Range | p Value | Multivariate OR (95% CI) | p Value | |
|---|---|---|---|---|---|---|---|
| PT (median) (s) | 11.8 | 12.6 | 12.4 | 11.2–13.8 | p > 0.05 | NA | NA |
| APTT (median) (s) | 29.4 | 27.5 | 28.2 | 21–34 | p > 0.05 | ||
| D-dimer (median) (ng/mL) (FEU) | 542 | 625 | 595 | 500 | p > 0.05 | ||
| FDP (median) (μg/mL) | 8.3 | 9.2 | 8.7 | 5 | p > 0.05 | ||
| Fibrinogen (median) (mg/dL) | 345 | 415 | 384 | 200–400 | p > 0.05 | ||
| Factor XII activity (median) (IU/dL) | 95 | 87 | 91 | 60–150 | p > 0.05 | ||
| Coagulation parameters during hospitalization | |||||||
| PT (median) (s) | 14.8 | 19.5 | 17.2 | 11.7–14.3 | p < 0.01 | 1.275 (1.023–1.590) | 0.031 |
| APTT (median) (s) | 39 | 58.5 | 43.5 | 22–36 | p < 0.01 | 1.074 (1.027–1.124) | 0.002 |
| D-dimer (median) (ng/mL) (FEU) | 648 | 1245 | 826 | 500 | p < 0.001 | - | - |
PT: Prothrombin time, APTT: Activated partial thromboplastin time, FDP: fibrin(ogen) degradation products.