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. 2021 May 9;22(9):5011. doi: 10.3390/ijms22095011

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The relationship between developmental stages and pluripotency states. ICM: inner cell mass; X: active X chromosome; Xi: inactive X chromosome; LIF: leukemia inhibitory factor; 2i: a medium consisting GSK3 and Mek1/2 inhibitors; bFGF: basic fibroblast growth factor; LCDM; a medium consisting of LIF, CHIR99021, (S)-(+)-dimethindene maleate, and minocycline hydrochloride; EPSC: extended pluripotent stem cells; PSC: pluripotent stem cells; iPSC: induced pluripotent stem cells; h: human; m: mouse; p: pig; b: bovine.