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Main differences between HBV and HCV pathogenesis.
| Virus | HBV | HCV |
|---|---|---|
| Viral family | Hepadnaviridae | Flaviviridae |
| Genome | DNA and cccDNA | RNA |
| Life cycle | Genome integration, expression of HBx protein, insertional activation of cellular oncogenes, cccDNA (minichromosome) | Exclusively cytoplasmic |
| Persistence | Nucleus-located cccDNA | Chronic inflammation, oxidative stress, alterations in cellular signaling and metabolism |
