Table 2.

Proteins of HCV reported being related to proteins of the ECM or cytokines. *, Direct interaction with the indicated HCV protein; ∞, modulation of expression; ◊, modulation of signaling.

HCV Proteins	ECM Proteins or Cytokines
Capsid core	LOX ∞ [61] Procollagen I ∞ [62] Collagen I ∞ [61] MMP-2 ∞ [58]
	MMP-9 ∞ [63]
	COX-2 ∞ [63]
	Syndecan-1 * [31]
	Thrombospondin-1 ∞ [61]
	Osteopontin * [64,65]
	CTGF ∞ [58]
	TGF-β1 ◊ [58,61,62,66]
	TGF-β2 ◊ [67]
	Endoglin ∞ [68]
Envelope glycoproteins E1 and/or E2	Glypican-3 * [69]
	TGF-β1 ◊ [66]
Cysteine autoprotease NS2	MICA ∞ [70] TGF-β2 ◊ [67]
Serine protease and helicase NS3	Procollagen I ∞ [62] MMP-9 ∞ [71]
	COX-2 ∞ [71]
	Thrombospondin-1 [72]
	Osteopontin * [64]
	TGF-β1 ◊ [62,72]
	TGF-β type I receptor * [73]
NS3 with its cofactor NS4A	MMP-9 ∞ [71]
	COX-2 ∞ [71] MICA ∞ [74]
	TGF-β ◊ [72,75]
NS4B	MMP-2 ∞ [76]
NS5A	MMP-2 ∞ [63]
	MMP-9 ∞ [63]
	COX-2 ∞ [63]
	Thrombospondin-1 ∞ [72]
	Osteopontin * [64]
	TGF-β1 ◊ [72,77,78]
RNA-dependent RNA polymerase NS5B	Osteopontin * [64]
	MICA ∞ [70] TGF-β ◊ [75]