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. 2021 May 8;13(9):2264. doi: 10.3390/cancers13092264

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The cytotoxic effects of HO-1 inhibitors and GEM or NPG combination on GEM-resistant cells by MTT. GEM-resistant and parental PDAC cells were treated with GEM or NPG for 48 h and tested for proliferation. T3M4 and T3M4-GR were treated with GEM or GEM with HO-1 inhibitors ZnPP (A) or SnPP (B), or HO-1 inducer CoPP (C). (D) MiaPaca-2 or MiaPaca-2-GR show similar results. (E) T3M4–GR cells were more sensitive to NPG in combination with HO-1 inhibitor (ZnPP). (F) Western blot analysis shows that GR cells increased HO-1 expression as compared to parental cells. Data are presented mean ± SEM. Please find the western bolt in supplementary file 1.