Table 2.
Immunosuppression maintenance treatment and medication non-adherence assessed by the Morisky scale over time.
| Follow-Up Visits | ||||
| Immunosuppression Maintenance Treatment | ||||
| M3 (N = 299) | M6 (N = 298) | M12 (N = 294) | M24 (N = 286) | |
| Tacrolimus, n (%) | 227 (75.9) | 228 (76.5) | 225 (76.5) | 216 (75.5) |
| Cyclosporine, n (%) | 65 (21.7) | 61 (20.5) | 55 (18.7) | 53 (18.5) |
| MMF, n (%) | 283 (94.6) | 266 (89.2) | 263 (89.4) | 251 (87.8) |
| Steroids, n (%) | 255 (85.3) | 203 (68.1) | 166 (56.5) | 142 (49.7) |
| CNI withdrawal, n (%) | 7 (2.3) | 9 (3.0) | 14 (4.8) | 17 (5.9) |
| Trough levels of tacrolimus, med (IQR) | 8.8 (7.3–10.8) | 8.2 (6.7–9.7) | 7.6 (6.4–9.3) | 7.5 (6.2–8.9) |
| Trough levels of cyclosporine, med (IQR) | 156 (130–190) | 149 (112–171) | 128.5 (96–157) | 93 (65–125) |
| Treatment Medication Non-Adherence Assessed by the Morisky Scale | ||||
| M3 (N = 272) | M6 (N = 263) | M12 (N = 269) | M24 (N = 234) | |
| Positive response to questions of the Morisky scale, n (%) | ||||
| Do you ever forget to take your medicine? | 19 (7.0) | 29 (10.9) | 40 (14.9) | 46 (19.5) |
| Are you careless at times about taking your medicine? | 33 (12.1) | 40 (15.2) | 54 (20.1) | 49 (20.8) |
| When you feel better, do you sometimes stop taking your medicine? | 2 (0.7) | 0 (0.0) | 2 (0.7) | 1 (0.4) |
| Sometimes if you feel worse when you take your medicine, do you stop taking it? | 6 (2.2) | 2 (0.7) | 3 (1.1) | 2 (0.8) |
| Non-adherent patients †, n (%) | 48 (17.6) | 62 (23.6) | 84 (31.2) | 81 (34.6) |
| Always non-adherent patients ‡, n (%) | 12 (4.0) | |||
| Score of the Morisky scale, n (%) | ||||
| 4 | 224 (82.4) | 201 (76.4) | 185 (68.8) | 153 (65.4) |
| 3 | 41 (15.1) | 54 (20.5) | 72 (26.8) | 66 (28.2) |
| ≤2 | 7 (2.6) | 8 (3.1) | 12 (4.4) | 15 (6.4) |
| Global score *, n (%) | ||||
| 16 | 96 (48.7) | |||
| 15 | 42 (21.3) | |||
| 13–14 | 42 (21.3) | |||
| ≤12 | 17 (8.6) | |||
M = month; N = subjects with available data; MMF = mycophenolate mofetil; med = median; IQR = interquartile range. † subjects with at least one positive response at Morisky scale; ‡ subjects without missing data with a positive response at each visit; * sum of positive response(s) of every Morisky scale at each time point for patients without missing data.