Table 3.
Effect of non-adherence measured by the Morisky scale and immunosuppression regimen on the risk of dnDSA apparition between 2 and 3 years post-transplant among patients with an available serum sample. Results of logistic regression model. Multivariable analysis.
| 3 Months (N ‡ = 200) | 6 Months (N ‡ = 193) | 12 Months (N ‡ = 198) | 24 Months (N ‡ = 174) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR * | CI 95% | p-Value | OR * | CI 95% | p-Value | OR * | CI 95% | p-Value | OR * | CI 95% | p-Value | |
| Non adherent vs. adherent † | 1.16 | 0.31–4.45 | 0.73 | 1.40 | 0.43–4.56 | 0.44 | 0.48 | 0.14–1.66 | 0.31 | 2.01 | 0.59–6.83 | 0.19 |
| Maintenance treatment | 0.005 | 0.04 | 0.009 | 0.005 | ||||||||
| Tacrolimus | 1 | 1 | 1 | 1 | ||||||||
| Cyclosporine | 5.2 | 1.65–16.4 | 2.49 | 0.76–8.16 | 4.67 | 1.48–14.76 | 5.17 | 1.34–20.01 | ||||
| Without anticalcineurin | 15.3 | 0.84–279.6 | 15.5 | 1.46–165.2 | 7.39 | 1.08–50.47 | 11.8 | 1.34–69.6 | ||||
| Recipient age (per year) | 0.97 | 0.93–1.01 | 0.06 | 0.96 | 0.92–0.99 | 0.02 | 0.96 | 0.92–0.99 | 0.03 | 0.97 | 0.93–1.02 | 0.15 |
| HLA mismatch (per number of mismatch) | 1.04 | 0.66–1.64 | 0.75 | 1.06 | 0.67–1.67 | 0.62 | 1.02 | 0.66–1.58 | 0.91 | 0.94 | 0.59–1.50 | 0.96 |
| Sensitized patients vs. non-sensitized patients | 0.21 | 0.03–1.72 | 0.91 | 0.21 | 0.03–1.74 | 0.95 | 0.18 | 0.02–1.42 | 0.78 | 0.21 | 0.03–1.74 | 0.81 |
OR: Odds ratio; CI: Confidence Interval; ‡ Subjects with complete data and with functioning graft at time of measure of NA; † Subjects with at least one positive response to Morisky scale at time of measure. * adjusted for adherence status, maintenance treatment, recipient age, HLA mismatch and sensitization at inclusion.