Table 4.

Effect of non-adherence measured by the Morisky scale and immunosuppression regimen (tacrolimus/cyclosporine/any anticalcineurin) on the hazard of graft failure since the third year post transplantation. Results of Cox proportional hazard model. Multivariable analysis.

	3 Months (N ‡ = 190)			6 Months (N ‡ = 183)			12 Months (N ‡ = 191)			24 Months (N ‡ = 169)
	HR *	CI 95%	p-Value	HR *	CI 95%	p-Value	HR *	CI 95%	p-Value	HR *	CI 95%	p-Value
Non adherent vs. adherent †	0.89	0.40–2.00	0.84	1.08	0.53–2.23	0.73	0.97	0.50–1.88	0.46	0.93	0.49–1.79	0.92
Recipient age (per year)	1.01	0.98–1.05	0.78	1.01	0.97–1.04	0.63	1.01	0.97–1.04	0.75	1.00	0.97–1.04	0.72
Donor age			0.68			0.91			0.71			0.24
<38 years	1			1			1			1
39–50 years	1.34	0.51–3.53		1.21	0.44–3.35		1.10	0.42–2.93		1.92	0.63–5.85
51–59 years	1.80	0.67–4.83		1.54	0.54–4.40		1.49	0.54–4.10		2.73	0.84–8.85
≥60 years	2.01	0.62–6.60		1.04	0.28–3.87		1.27	0.37–4.38		3.67	0.97–13.9
Maintenance treatment			0.37			0.27			0.97			0.15
Tacrolimus	1			1			1			1
Cyclosporine	0.90	0.46–1.78		1.30	0.69–2.45		0.86	0.45–1.65		0.76	0.37–1.56
Any anticalcineurin	0.46	0.06–3.56		0.26	0.03–2.02		0.71	0.21–2.38		1.20	0.45–3.23
Occurrence of acute rejection (time-dependent variable)	2.64	1.34–5.16	0.0005	2.65	1.43–4.90	0.002	1.92	1.06–3.49	0.03	1.90	0.98–3.67	0.055
Occurrence of dnDSA between 2 and 3 years post-transplant	2.42	1.02–5.75	0.03	3.51	1.49–8.25	0.002	2.30	1.03–5.12	0.04	1.84	0.74–5.23	0.19

HR: Hazard ratio; CI: Confidence Interval; ^‡ Subjects with complete data and with a functioning graft at 3 years post-transplant; ^† Subjects with at least one positive response to Morisky scale at time of measure. * adjusted for recipient and donor age, maintenance treatment at time of measure of NA, occurrence of acute rejection (time dependent variable) and occurrence of dnDSA between 2 and 3 years post transplant.