Table 2.
MIC and MBC values of P7 and of the monomer M7 against bacteria of Gram-positive species, obtained from experiments carried out in triplicate 1, expressed as µM and as µg/mL.
| P7 (13719) 2 | M7 (274) 2 | |||
|---|---|---|---|---|
| Strains | MIC µM (µg/mL) |
MBC µM (µg/mL) |
MIC µM (µg/mL) |
MBC µM (µg/mL) |
| Enterococcus Genus | ||||
| E. faecalis 1 * | 2.3 (32) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| E. faecalis 18 * | 2.3 (32) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| E. faecalis 51 * | 2.3 (32) | 4.6 (64) | 233.6 (64) | 467.1 (128) |
| E. faecalis 365 * | 2.3 (32) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| E. faecium 325 * | 1.15 (16) | 2.3 (32) | 116.8 (32) | 233.6 (64) |
| E. faecium 341 * | 1.15 (16) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| E. faecium 364 * | 0.6 (8) | 1.15 (16) | 233.6 (64) | 467.1 (128) |
| Minor Strains | ||||
| E. casseliflavus 184 ° | 1.15 (16) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| E. durans 103 ° | 1.15 (16) | 2.3 (32) | 467.1 (128) | 934.3 (256) |
| E. gallinarum 150 * | 1.15 (16) | 2.3 (32) | 467.1 (128) | 467.1 (128) |
| Staphylococcus Genus | ||||
| S. aureus 18 ** | 4.6 (64) | 4.6 (64) | 233.6 (64) | 467.1 (128) |
| S. aureus 195 ** | 4.6 (64) | 4.6 (64) | 233.6 (64) | 467.1 (128) |
| S. aureus 189 | 4.6 (64) | 4.6 (64) | 233.6 (64) | 467.1 (128) |
| S. epidermidis 22 ** | 1.15 (16) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| S. epidermidis 180 *** | 1.15 (16) | 2.3 (32) | 116.8 (32) | 233.6 (64) |
| S. epidermidis 181 *** | 1.15 (16) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| S. haemolyticus 193 ** | 3.15 (16) | 3.15 (16) | 233.6 (64) | 233.6 (64) |
| S. hominis 125 ** | 0.6 (8) | 0.6 (8) | 116.8 (32) | 116.8 (32) |
| S. lugdunensis 129 | 1.15 (16) | 1.15 (16) | 116.8 (32) | 233.6 (64) |
| S. warneri 74 | 1.15 (16) | 1.15 (16) | 233.6 (64) | 233.6 (64) |
| S. saprophyticus 41 | 1.15 (16) | 2.3 (32) | 116.8 (32) | 233.6 (64) |
| S. simulans 163 ** | 1.15 (16) | 1.15 (16) | 467.1 (128) | 467.1 (128) |
| Sporogenic Isolate | ||||
| B. subtilis | 1.15 (16) | 1.15 (16) | 233.6 (64) | 467.1 (128) |
1 the degree of concordance was 3/3 in all the experiments, and standard deviation (±SD) was zero; 2 Mn of copolymer P7 and MW of monomer M7; * denotes vancomycin resistance (VRE); ° denotes intrinsic resistance to vancomycin; ** denotes methicillin resistance; *** denotes resistance toward methicillin and linezolid.