Table 3.
MIC and MBC values of P7 and of the monomer M7 against bacteria of Gram-negative species, obtained from experiments carried out in triplicate 1, expressed as µM and as µg/mL.
| P7 (13719) 2 | M7 (274) 2 | |||
|---|---|---|---|---|
| Strains | MIC µM (µg/mL) |
MBC µM (µg/mL) |
MIC µM (µg/mL) |
MBC µM (µg/mL) |
| Enterobacteriaceae Family | ||||
| E. coli 224 S | 2.3 (32) | 2.3 (32) | 467.1 (128) | 467.1 (128) |
| E. coli 238 # | 4.6 (64) | 4.6 (64) | 934.3 (256) | 934.3 (256) |
| E. coli 246 § | 2.3 (32) | 2.3 (32) | 467.1 (128) | 467.1 (128) |
| Y. enterocolitica 342 | 9.3 (128) | 18.6 (256) | 467.1 (128) | 934.3 (256) |
| S. marcescens 228 | >18.6 (>256) | nt 3 | 1868.6 (512) | 1868.6 (512) |
| P. mirabilis 254 | 18.6 (256) | 18.6 (256) | 1868.6 (512) | 1868.6 (512) |
| M. morganii 372 | 18.6 (256) | >18.6 (>256) | 1868.6 (512) | 1868.6 (512) |
| K. oxytoca 252 | 9.3 (128) | 9.3 (128) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 231 # | 4.6 (64) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 232 # | 9.3 (128) | 18.6 (256) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 233 # | 4.6 (64) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 260 # | 9.3 (128) | 9.3 (128) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 366 # | 4.6 (64) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 367 # | 9.3 (128) | 9.3 (128) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 369 | 9.3 (128) | 18.6 (256) | 467.1 (128) | 467.1 (128) |
| K. pneumoniae 377 S | 4.6 (64) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| Salmonella gr. B 227 | 4.6 (64) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| P. stuartii 374 | 9.3 (128) | 9.3 (128) | 1868.6 (512) | 1868.6 (512) |
| Non-Fermenting Species | ||||
| A. baumannii 257 | 2.3 (32) | 4.6 (64) | 467.1 (128) | 934.3 (256) |
| A. baumannii 279 | 2.3 (32) | 2.3 (32) | 467.1 (128) | 467.1 (128) |
| A. baumannii 236 | 9.3 (128) | 9.3 (128) | 233.6 (64) | 467.1 (128) |
| A. baumannii 245 | 9.3 (128) | 4.6 (64) | 467.1 (128) | 934.3 (256) |
| A. baumannii 383 | 4.6 (64) | 4.6 (64) | 467.1 (128) | 467.1 (128) |
| A. pittii 272 | 2.3 (32) | 2.3 (32) | 233.6 (64) | 467.1 (128) |
| P. aeruginosa 229 | 4.6 (64) | 4.6 (64) | >1868.6 (>512) | nt 3 |
| P. aeruginosa 247 | 4.6 (64) | 9.3 (128) | >1868.6 (>512) | nt 3 |
| P. aeruginosa 256 | 4.6 (64) | 4.6 (64) | >1868.6 (>512) | nt 3 |
| P. aeruginosa 259 | 9.3 (128) | 18.6 (256) | >1868.6 (>512) | nt 3 |
| P. aeruginosa 268 | 4.6 (64) | 4.6 (64) | >1868.6 (>512) | nt 3 |
| P. aeruginosa 269 | 2.3 (32) | 2.3 (32) | >1868.6 (>512) | nt 3 |
| P. fluorescens 278 | 2.3 (32) | 2.3 (32) | 934.3 (256) | 934.3 (256) |
| P. putida 262 | 4.6 (64) | 4.6 (64) | 934.3 (256) | 934.3 (256) |
| S. maltophylia 255 | 9.3 (128) | 18.6 (256) | 467.1 (128) | 934.3 (256) |
| S. maltophylia 280 | 4.6 (64) | 9.3 (128) | 467.1 (128) | 934.3 (256) |
| S. maltophylia 2 | 2.3 (32) | 2.3 (32) | 467.1 (128) | 467.1 (128) |
| S. maltophylia 3 | 4.6 (64) | 9.3 (128) | 467.1 (128) | 467.1 (128) |
| S. maltophylia 4 | 2.3 (32) | 4.6 (64) | 233.6 (64) | 233.6 (64) |
| S. maltophylia 5 | 9.3 (128) | 18.6 (256) | 467.1 (128) | 467.1 (128) |
1 the degree of concordance was 3/3 in all the experiments, and standard deviation (±SD) was zero; 2 Mn of copolymer P7 and MW of monomer M7; 3 means not tested; S denotes susceptibility to all antibiotics; # denotes carbapenemase (KPC)-producing. § denotes O157:H7; P. aeruginosa, S. maltophylia and A. baumannii are all MDR bacteria.