Table 2.
11 | IC50 = 1.3 µM (S. mansoni NTS) IC50 = 0.7 µM (adult S. mansoni) |
Cowan et al., 2015 [113] | |
12 | IC50 = 0.2 µM (adult S. mansoni) | Cowan et al., 2015 [113] | |
13 | IC50 = 3.6 µM (adult S. mansoni) | Cowan et al., 2015 [113] | |
14 | IC50 = 7.0 µM (adult S. mansoni) | Cowan et al., 2015 [113] | |
15 | IC50 = 0.15 µM (S. mansoni NTS) IC50 = 0.19 µM (adult S. mansoni) |
Wu et al., 2018 [114] | |
16 | IC50 = 2.5 µM (juvenile S. japonicum) IC50 = 1.5 µM (adult S. japonicum) |
Yao et al., 2016 [115] | |
MMV665852 | IC50 = 4.7 µM (S. mansoni NTS) IC50 = 0.8 µM (adult S. mansoni) IC50 = 4.4 µM (juvenile S. japonicum) IC50 = 2.2 µM (adult S. japonicum) EC50 = 1160 nM (P. falciparum) |
Ingram-Sieber et al., 2014 [116] Yao et al., 2016 [115] |
|
Flucofuron | IC50 = 2.8 µM (juvenile S. japonicum) IC50 = 1.5 µM (adult S. japonicum) |
Yao et al., 2016 [115] | |
17 | C50 = 4.26 µM (antiglycating activity) | Khan et al., 2009 [117] | |
18 | IC50 = 4.26 µM (antiglycating activity) | Khan et al., 2009 [117] | |
CP-214339 | IC50 = 0.13 µM (Δ5-desaturase inhibitor in rodents) |
Obukowicz et al., 1998 [118] | |
19 | IC50 = 18.4 µg/mL (proton pump inhibition) |
Rakesh et al., 2017 [119] | |
20 | IC50 = 20.3 µg/mL (anti-inflammatory activity in human blood) |
Rakesh et al., 2017 [119] | |
21 |
Ki = 0.56 µM (TRPV1 capsaicin antagonism) |
Feng et al., 2016 [120] |