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. 2021 May 10;26(9):2811. doi: 10.3390/molecules26092811

Table 2.

Analogues of triclocarban with various activities.

graphic file with name molecules-26-02811-i013.jpg 11 IC50 = 1.3 µM (S. mansoni NTS)
IC50 = 0.7 µM (adult S. mansoni)
Cowan et al., 2015 [113]
graphic file with name molecules-26-02811-i014.jpg 12 IC50 = 0.2 µM (adult S. mansoni) Cowan et al., 2015 [113]
graphic file with name molecules-26-02811-i015.jpg 13 IC50 = 3.6 µM (adult S. mansoni) Cowan et al., 2015 [113]
graphic file with name molecules-26-02811-i016.jpg 14 IC50 = 7.0 µM (adult S. mansoni) Cowan et al., 2015 [113]
graphic file with name molecules-26-02811-i017.jpg 15 IC50 = 0.15 µM (S. mansoni NTS)
IC50 = 0.19 µM (adult S. mansoni)
Wu et al., 2018 [114]
graphic file with name molecules-26-02811-i018.jpg 16 IC50 = 2.5 µM (juvenile S. japonicum)
IC50 = 1.5 µM (adult S. japonicum)
Yao et al., 2016 [115]
graphic file with name molecules-26-02811-i019.jpg MMV665852 IC50 = 4.7 µM (S. mansoni NTS)
IC50 = 0.8 µM (adult S. mansoni)
IC50 = 4.4 µM (juvenile S. japonicum)
IC50 = 2.2 µM (adult S. japonicum)
EC50 = 1160 nM (P. falciparum)
Ingram-Sieber et al., 2014 [116]
Yao et al., 2016 [115]
graphic file with name molecules-26-02811-i020.jpg Flucofuron IC50 = 2.8 µM (juvenile S. japonicum)
IC50 = 1.5 µM (adult S. japonicum)
Yao et al., 2016 [115]
graphic file with name molecules-26-02811-i021.jpg 17 C50 = 4.26 µM (antiglycating activity) Khan et al., 2009 [117]
graphic file with name molecules-26-02811-i022.jpg 18 IC50 = 4.26 µM (antiglycating activity) Khan et al., 2009 [117]
graphic file with name molecules-26-02811-i023.jpg CP-214339 IC50 = 0.13 µM
(Δ5-desaturase inhibitor in rodents)
Obukowicz et al., 1998 [118]
graphic file with name molecules-26-02811-i024.jpg 19 IC50 = 18.4 µg/mL
(proton pump inhibition)
Rakesh et al., 2017 [119]
graphic file with name molecules-26-02811-i025.jpg 20 IC50 = 20.3 µg/mL
(anti-inflammatory activity in human blood)
Rakesh et al., 2017 [119]
graphic file with name molecules-26-02811-i026.jpg 21 Ki = 0.56 µM
(TRPV1 capsaicin antagonism)
Feng et al., 2016 [120]