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Chemical structure of CAIs 1–7 investigated as protective agents in cerebral ischemia. Except acetazolamide 1, which is a CA pan-inhibitor [18], compounds 2–7 show a selective inhibition of some CA isoforms present in the brain, such as CA VII, or of the two isoforms overexpressed in hypoxia, CA IX and XII, for which they act as low nanomolar inhibitors.
