Table 5.

Comparison of the HAS-BLED score and prior major bleeding in predicting of future major bleeding event according to multivariable Cox proportional hazard models in the study population

Variable	HR	95% CI	P value
HAS-BLED score
Crude
HAS-BLED (↑ per unit)	0.89	0.63–1.27	0.53
Multivariable models
1. Crude + INR	0.80	0.54–1.19	0.27
2. 1 + Comorbidity index + Functional status	0.70	0.44–1.12	0.19
3. 2 + Dual antiplatelet therapy + Kt/V + PPI use	0.76	0.47–1.20	0.24
4. 3 + All-cause death	0.76	0.48–1.22	0.25
Prior Major Bleeding
Crude
Prior Major Bleeding (yes)	2.30	1.00–5.27	0.05
Multivariable models
1. Crude + INR	1.65	0.62–4.24	0.30
2. 1 + Comorbidity index + Functional status	2.05	0.63–6.72	0.23
3. 2 + Dual antiplatelet therapy + Kt/V + PPI use	2.10	0.67–6.59	0.20
4. 3 + All-cause death	2.07	0.62–6.92	0.24

Abbreviations: INR international normalized ratio, PPI proton-pump inhibitor