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Local charge calculations for the R112C domains of ApoE3/4 and LDL−A repeats. (A) Local charges of R112C domain from ApoE3 (red line) and ApoE 4 (black line) were calculated as a function of pH in the range between 4 and 8. (B) Local charges of each of seven LDL−A domains were calculated as a function of pH in the range between 4 and 8. The charge value curve for each LDL−A repeat is color-coded as on panel 1A.
