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. 2021 May 10;22(9):5030. doi: 10.3390/ijms22095030

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The product of ionic charges (α) of electrostatic interactions between R112C domains of ApoE3/4 and LDL−A repeats (A,B). The product of ionic charges (α) of the R112C domain from ApoE3 (A) and ApoE4 (B) and each of the seven LDL−A repeats is shown as a function of pH in the range between 4 and 8. The values of α for each LDL-A repeat are color coded as on panel 1A. (C) Average value of α for all LDL−A repeats are shown as a function of pH in the range between 4 and 8 for ApoE3 (red line) and ApoE4 (black line).