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. 2021 May 10;22(9):5030. doi: 10.3390/ijms22095030

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Endocytosis and recycling of ApoE3 and ApoE4-containing LDLR complexes. Surface LDLR (R) form complexes with ApoE3 (E3) and ApoE4 (E4) at plasma membrane (PM). Following internalization after clathrin-mediated endocytosis, these complexes are moved from the very early endosomal (VEE) compartment to the endosomal compartment (EE) and the late endosomal compartment (LE). Dissociation of ApoE allows recycling of LDLR to the plasma membrane. The LDLR trapped in LE compartments are targeted for degradation by lysosomes. The range of pH values for each endosomal compartment is indicated.