Table 5.

Toxicity properties of isoflavonoids (1–59) and semiprever.

Comp.	FDA Rodent Carcinogenicity	Carcinogenic Potency TD50 (Rat) a	Rat MTD (Feed) b	Rat Oral LD50 c	Rat Chronic LOAEL d	Ocular Irritancy	Skin Irritancy
1	Non-Carcinogen	60.47	0.516	1.40	0.107	Irritant	None
2	Non-Carcinogen	67.14	0.334	1.41	0.089	Irritant	None
3	Non-Carcinogen	10.43	0.225	0.81	0.068	Irritant	None
4	Non-Carcinogen	5.69	0.231	0.17	0.072	Irritant	None
5	Non-Carcinogen	5.73	0.234	0.17	0.071	Irritant	None
6	Carcinogen	35.33	0.239	0.77	0.024	Irritant	None
7	Non-Carcinogen	6.23	0.096	0.48	0.019	Irritant	None
8	Non-Carcinogen	33.45	0.529	1.06	0.074	Irritant	Mild
9	Carcinogen	4.43	0.122	0.14	0.027	Irritant	Mild
10	Carcinogen	28.52	0.126	0.16	0.011	Irritant	None
11	Non-Carcinogen	7.51	0.192	0.55	0.015	Irritant	None
12	Non-Carcinogen	193.96	0.078	0.10	0.004	Mild	None
13	Non-Carcinogen	5.27	0.255	1.07	0.865	Mild	None
14	Non-Carcinogen	9.10	0.164	1.13	0.325	Mild	None
15	Non-Carcinogen	7.32	0.288	2.03	0.147	Mild	None
16	Non-Carcinogen	7.91	0.230	1.67	0.155	Mild	None
17	Non-Carcinogen	8.98	0.184	1.18	0.152	None	None
18	Non-Carcinogen	8.40	0.205	1.69	0.309	Mild	None
19	Non-Carcinogen	0.77	0.069	0.39	0.130	None	Mild
20	Non-Carcinogen	0.59	0.061	0.20	0.145	None	Mild
21	Non-Carcinogen	6.40	0.181	1.44	0.229	Mild	None
22	Non-Carcinogen	5.73	0.205	2.36	0.390	Mild	None
23	Non-Carcinogen	0.44	0.077	0.42	0.282	Mild	Mild
24	Non-Carcinogen	6.88	0.288	4.66	0.863	Mild	None
25	Non-Carcinogen	19.50	0.181	0.97	0.191	None	None
26	Non-Carcinogen	10.75	0.145	1.01	0.281	Mild	None
27	Non-Carcinogen	29.81	0.184	1.74	0.054	Mild	None
28	Non-Carcinogen	19.03	0.199	0.77	0.035	None	None
29	Non-Carcinogen	25.03	0.080	0.35	0.055	Severe	None
30	Non-Carcinogen	2.33	0.097	0.45	0.039	Severe	None
31	Non-Carcinogen	2.33	0.097	0.45	0.039	Severe	None
32	Non-Carcinogen	20.46	0.128	0.26	0.074	Mild	None
33	Non-Carcinogen	73.66	0.197	0.29	0.013	Mild	Mild
34	Non-Carcinogen	25.44	0.526	0.92	0.018	Severe	None
35	Non-Carcinogen	6.87	0.236	0.37	0.013	Mild	None
36	Non-Carcinogen	322.42	0.764	0.84	0.029	Severe	None
37	Non-Carcinogen	165.35	0.303	1.39	0.008	Mild	None
38	Non-Carcinogen	19.21	0.153	0.46	0.024	Mild	None
39	Non-Carcinogen	35.43	0.576	0.70	0.012	Severe	None
40	Non-Carcinogen	4.926	0.216	0.44	0.015	Mild	None
41	Non-Carcinogen	6.31	0.381	0.98	0.075	Severe	None
42	Non-Carcinogen	5.95	0.428	0.71	0.026	Mild	None
43	Non-Carcinogen	6.31	0.381	0.91	0.044	Mild	None
44	Non-Carcinogen	5.81	0.475	1.12	0.041	Mild	None
45	Non-Carcinogen	5.28	0.402	0.76	0.037	Mild	None
46	Non-Carcinogen	3.25	0.668	1.10	0.174	Mild	None
47	Non-Carcinogen	4.02	0.395	0.65	0.084	None	None
48	Non-Carcinogen	126.90	0.545	0.39	0.009	Severe	None
49	Non-Carcinogen	14.44	0.284	0.32	0.024	Mild	None
50	Non-Carcinogen	14.44	0.284	0.20	0.008	Mild	None
51	Non-Carcinogen	16.34	0.226	0.14	0.008	Mild	None
52	Non-Carcinogen	21.43	0.226	0.46	0.010	Mild	None
53	Non-Carcinogen	18.79	0.150	0.34	0.008	Mild	None
54	Non-Carcinogen	18.79	0.150	0.26	0.007	Mild	None
55	Non-Carcinogen	14.61	0.226	0.32	0.053	Severe	None
56	Non-Carcinogen	116.75	0.562	0.42	0.006	Severe	None
57	Non-Carcinogen	177.62	0.291	0.36	0.004	Severe	None
58	Non-Carcinogen	5.28	0.156	0.18	0.016	Mild	None
59	Non-Carcinogen	15.21	0.208	0.35	0.014	Mild	None
Simeprevir	Non-Carcinogen	0.28	0.003	0.21	0.002	Irritant	None

^a TD ₅₀, tumorigenic dose rate 50, Unit: mg kg⁻¹ body weight/day; ^b MTD, maximum tolerated dose, Unit: g kg⁻¹ body weight; ^c LD₅₀, median lethal dose, Unit: g kg⁻¹ body weight; ^d LOAEL, lowest observed adverse effect level, Unit: g kg⁻¹ body weight.