Table 3.
Analysis of the drug interaction between PLX4032, orlistat and U18666 A in LM16 R cells 1.
| PLX4032 | Orlistat (µM) | U18666A (µM) | CI 2 |
|---|---|---|---|
| 10 µM | 10 µM | 10 µM | 0.28 ± 0.17 |
| 10 µM | 10 µM | 3 µM | 0.37 ± 0.36 |
| 10 µM | 3 µM | 10 µM | 0.30 ± 0.26 |
| 10 µM | 3 µM | 3 µM | 0.31 ± 0.05 |
| 3 µM | 10 µM | 10 µM | 0.43 ± 0.00 |
| 3 µM | 10 µM | 3 µM | 0.64 ± 0.12 |
| 3 µM | 3 µM | 10 µM | 0.26 ± 0.25 |
| 3 µM | 3 µM | 3 µM | 0.61 ± 0.26 |
1 Cell sensitivity was assessed by cell growth inhibition assay. 2 Combination Index (CI) values show synergistic drug interactions. CI are the mean ± SE of three independent experiments.