Table 2.

Multivariate survival analysis

	HR	95% CI for HR	P value
Disease control rate*
CAIX/I	NA	NA	0.028
CD8	NA	NA	0.005
PFS
CAIX/I† (high)	1.71	1.03 to 2.84	0.04
CD8‡ (high)	0.08	0.006 to 1.131	0.02
OS
CAIX/I (high)	1.68	0.87 to 3.22	0.11
CD8 (high)	0.065	0.001 to 3.78	0.081
Programmed death-ligand 1 (PD-L1)	0.98	0.93 to 1.02	0.20

*Disease control rate=CR, PR, or SD.

†CAIX/I=per cent area of CAIX/intensity of CAIX dichotomized.

‡CD8=CD8 T cells normalized to tumor area. Only variables significant in univariate analysis were included in multivariate model.

OS, overall survival; PFS, progression free survival.