Table 2.

Immune-related adverse events

	Delayed ipilimumab arm (n=26)					Immediate ipilimumab arm (n=24)
	Grade 1	Grade 2	Grade 3	Grade 4	Total	Grade 2	Grade 3	Total
Adrenal insufficiency	1 (3.8%)	1 (3.8%)	1 (3.8%)	0	3 (11.5%)	1 (4.2%)	0	1 (4.2%)
Diarrhea	2 (7.7%)	0	3 (11.5%)	1 (3.8%)	6 (23.1%)	2 (8.3%)	1 (4.2%)	3 (12.5%)
Hyperthyroidism	2 (7.7%)	1 (3.8%)	0	0	3 (11.5%)	0	0	0
Hypothyroidism	1 (3.8%)	0	0	0	1 (3.8%)	1 (4.2%)	0	1 (4.2%)
Lipase increased	0	0	1 (3.8%)	0	1 (3.8%)	0	2 (8.3%)	2 (8.3%)
Rash	1 (3.8%)	1 (3.8%)	0	0	2 (7.7%)	2 (8.3%)	1 (4.2%)	3 (12.5%)
No of patients (%)	7 (26.9%)	2 (7.7%)	3 (11.5%)	1 (3.8%)	13 (50%)	5 (20.8%)	3 (12.5%)	8 (33.3%)