Figure 2. Expression levels of miRNA-4525 and miRNA-4534 in extracellular vesicles (EVs) isolated from patients with renal cell carcinoma (RCC). miRNA-4525 expression in serum EVs significantly was increased in patients with advanced RCC compared with healthy controls, whereas miRNA-4534 expression was not. Cel-miR-39-3p was used as spike-in control for standardization. Bars and lines represent the median and 95% confidence interval, respectively.