. Author manuscript; available in PMC: 2021 May 16.

Published in final edited form as: Int J Infect Dis. 2021 Mar 5;105:688–694. doi: 10.1016/j.ijid.2021.03.001

Table 5.

Covariates associated with new or worsening depression and/or psychosis in 144 patients treated with terizidone for multidrug-resistant tuberculosis.

	HR (95% CI)	P-value
Age	1.02 (0.98–1.07)	0.325
Sex	1.21 (0.48–3.07)	0.692
HIV	1.09 (0.43–2.77)	0.855
Previous TB treatment	0.78 (0.29–2.04)	0.608
History of alcohol use	0.99 (0.38–2.63)	0.999
History of recreational drug use	1.12 (0.46–2.76)	0.804
Isoniazid use	0.78 (0.23–2.69)	0.699
Efavirenz use	1.06 (0.43–2.65)	0.895
Cycloserine AUC_0–24 (per 100 unit increase)	0.86 (0.71–1.05)	0.134
Cycloserine C_max	0.97 (0.94–1.01)	0.160
C_max >35 μg/mL	1.00 (0.40–2.52)	0.999
Trough concentration (C₂₄)	0.96 (0.92–1.01)	0.161
Clearance, l/h	1.22 (0.38–3.94)	0.736

HR, hazard ratio; CI, confidence interval.