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. 2021 May 13;38(11):1535–1550. doi: 10.1089/neu.2020.7575

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Copyright 2021, Mary Ann Liebert, Inc., publishers

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FIG. 3. — Treatment with exosomes significantly reduces hippocampal neuronal cell loss after traumatic brain injury (TBI). Neuronal nuclei (NeuN) staining was performed for detection of mature neurons at day 35 after TBI in the dentate gyrus (DG) region (A–D) and CA3 region (E-–H). Both Exo-empty and Exo-17-92 treatments administered intravenously 24 h after TBI reduced the NeuN+ cell loss in the DG (C and D) and CA3 region (G and H) compared with Vehicle treatment (B and F). Compared with the Exo-empty (C and G), Exo-17-92 exhibited significantly better effects on reducing the neuronal cell loss in the DG region (D) and CA 3 region (H). Scale bars = 100 μm (H). Quantitative data shown in bar graph (I) represent mean ± SD. N = 8/group. Color image is available online.