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. 2021 May 13;38(11):1551–1571. doi: 10.1089/neu.2020.7254

FIG. 4.

FIG. 4.

Cued (delayed) fear conditioning/extinction was not affected by bTBI. (A) Schematic illustration of the cued fear conditioning/extinction task. Fear conditioning/extinction/retrieval/renewal tests (block of 3 days) were performed 1, 2, 4, and 8 weeks after 1 × Blast and 3 days, 2 weeks, and 8 weeks after 4 × Blast. The test sequence is described in the Methods. (B) Percent freezing data for 1, 2, 4, and 8 weeks after 1 × Blast. n = 7 for 1 × Sham, and n = 7 for 1 × Blast at 1, 4, and 8 weeks. n = 6 for 1 × Sham and n = 5 for 1 × Blast at 2 weeks. COND, fear conditioning; EXT, extinction training; RET, retrieval test; REN; fear renewal test; BL, baseline; CS 03, third CS; CS 01–05, average of first five CSs; CS 45–50, average of last five CSs. (C) Percent freezing data for 3 days, 2 weeks, and 8 weeks after 4 × Blast. n = 12 for 4 × Sham and n = 13 for 4 × Blast at 3 days, n = 15 for 4 × Sham and n = 22 for 4 × Blast at 2 weeks, n = 19 for 4 × Sham and n = 22 for 4 × Blast at 8 weeks. Data are mean ± SEM. bTBI, blast traumatic brain injury; CS, conditioned stimulus; SEM, standard error of the mean. Color image is available online.