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. 2021 May 13;38(11):1585–1606. doi: 10.1089/neu.2021.0025

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© Laura B. Tucker, Amanda H. Fu, and Joseph T. McCabe 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 1. — Apnea (A) and recovery of righting reflexes (B) following Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) injury or sham treatment each day. Legend in (B) applies to both panels. Represented in (A) are specific instances of apnea each day of injury. There were very few incidences of apnea following injury (none after sham procedures), and they tended to occur after the earlier injuries. The righting reflex (time to return to a prone position after being placed supine following discontinuation of anesthesia) is shown in (B). On all injury days, both male and female injured mice took significantly longer to right themselves than their sex-matched sham-treated mice (***p < 0.001 for all days, CHIMERA > Sham).