Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 13;38(11):1585–1606. doi: 10.1089/neu.2021.0025

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Laura B. Tucker, Amanda H. Fu, and Joseph T. McCabe 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

PMC Copyright notice

FIG. 2. — Axonal degeneration as observed by silver staining in the optic tracts (OT; A), corpus callosum (CC; B), fimbria (FI; C), and cerebral peduncles (CP; D). Scale bars in (A) and (C) represent 100 μm, (B) and (D) represent 200 μm. Photomicrographs on the right are enlarged images of the boxed regions; scale bars of enlarged regions represent 20 μm (A), (C) and (D), or 50 μm (B). Arrows in enlarged regions point to silver-stained punctate or argyrophilic fibers. All injured mice showed prominent silver staining in the OTs (A), and readily observable silver staining in the CC (B, with enlarged region). About one-third of mice (both male and female) had sparse silver staining in the FI, lateral to CA2, observable with higher magnification (C, enlarged region). Most injured animals also showed white matter damage in the CPs, which was only readily observable at higher magnification (D, enlarged region).