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. 2021 May 13;38(11):1585–1606. doi: 10.1089/neu.2021.0025

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© Laura B. Tucker, Amanda H. Fu, and Joseph T. McCabe 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (CC-BY) (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 7. — Performance during learning trials in the Morris water maze. Legend in (C) applies to all panels. Injured mice were impaired during both standard and reversal learning as measured by the latency to find the hidden platform (A). There was a significant main effect of Injury on the latency to locate the platform during the standard trials; during reversal training trials, Closed-Head Impact Model of Engineered Rotational Acceleration (CHIMERA) only had an effect in male mice. When distance swam was analyzed (B), the effect of injury was limited to the 3rd standard training day (post-injury Day 26). Swim speed (C) was significantly affected by Injury during both standard and reversal training trials. All injured mice were impaired on the visible platform trials (A and B). Asterisks (*) in (A) and (B) represent an effect of Injury on the given day/trial; in (C) represent a main effect of Injury during standard and reversal trials, CHIMERA < Sham: ***p < 0.001; **p < 0.01. The at symbol (@) in (A) indicates an effect of Injury in male mice only on the represented day, Male CHIMERA > Male Sham; @@@p < 0.001.