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. 2021 Feb 8;5(5):455–466. doi: 10.1038/s41551-020-00675-9

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© The Author(s), under exclusive licence to Springer Nature Limited 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–f, Free cGAMP alone is unable to activate STING, whereas PC7A NPs and cGAMP-loaded PC7A NPs demonstrate effective STING activation. Fresh surgically resected sentinel lymph nodes (SLN) (a,b) or squamous cell carcinoma samples from the base of tongue (SCC-BOT) (c–f) were divided into multiple sections (1–5 mm³) and injected with 5% glucose, free cGAMP, PC7A NPs or cGAMP-loaded PC7A NPs in 5% glucose solutions. IFNB1 (a,c,e) and CXCL10 (b,d,f) gene expression was measured after 24 h incubation. e,f, The CD45⁺ cell population exhibited an enhanced level of STING activation compared with CD45⁻ cells. Data are mean ± s.d. n = 4 SLN sections from the same patient in a and b. n = 4 SCC-BOT tumour sections from the same patient in c–f. Statistical analysis was performed using two-tailed Student’s t-tests.