Fig. 2.

Graphical summary of the results. Physically inactive APOE ε4 carriers may have lower cognitive functioning, CBF, HDL cholesterol, BDNF and higher Aβ accumulation, LDL cholesterol and neuroinflammation factors such as TNF- α, IL-1β and IL-6 compared to physically active APOE ε4 carriers. Physical activity may be involved in the reduction of Aβ accumulation, LDL cholesterol, neuroinflammation factors such as TNF- α, IL-1β and IL-6 and in the increase of cognitive functioning, HDL cholesterol, CBF and BDNF in APOE ε4 carriers. Aβ amyloid-β, HDL-c high density lipoprotein cholesterol, LDL-c low density lipoprotein cholesterol, CBF cerebral blood flow, BDNF brain-derived neurotrophic factor, TNFα tumor necrose factor α, IL-1β interleukin-1β, IL-6 interleukin-6