Table 1.

Summary of data from studies employing POCT for D-dimer testing in a primary care setting meeting the inclusion criteria

Authora	Suspected condition	Study type	Main question	Nb	Decision rulea	Confirmation of diagnosis	Key findings
Buller 2009 [22]	DVT	Prospective management study	Diagnostic performance	1002	Oudega [9]	Ultrasonography +  3-month follow up	49% ruled out; false negative rate 1.4% (95% CI 0.6–2.9%); 49% ruled in: 25% positive by ultrasonography
Geersing 2010 [24]	DVT	Cross sectional survey	Clinical probability assessed by GP vs decision rule	1002	Oudega [9]	Ultrasonography +  3-month follow-up	False negative rate 3 and 7 in clinical probability and decision rule, respectively; more ruled out correctly: 493 vs 188 and 296 for clinical probability of 10% and 20%
Van der Velde 2011 [25]	DVT	Post-hoc analysis	Comparison of Wells and Oudega rules	1002	Oudega [9] and Wells [32]	Ultrasonography +  3-month follow-up	45% and 49% ruled out using Wells and Oudega rules, respectively; false negative rate: 1.7% and 1.4%, respectively
Janssen 2011 [26]	DVT	Prospective study with updating tools	Impact of additional predictors to Oudega rule	1002	Oudega [9]	Ultrasonography +  3-month follow-up	Original diagnostic score not improved on Buller (22) findings
Geersing 2012 [23]	PE	Prospective cohort/validation study	Diagnostic performance	598	Wells PE [20]	Composite imaging methods and independent adjudication committee	45% rule out; false negative rate with a Wells score of ≤ 4 and negative D-dimer: 1.5%
Lucassen 2015 [27]	PE	Post-hoc analysis	Comparison between qualitative and quantitative tests	598	Wells PE [20]	Composite imaging methods and independent adjudication committee	45% and 42% rule out with qualitative and quantitative tests, respectively; false negative rates: 1.5% and 0.4%, respectively
Hendriksen 2015 [28]	PE	Validation study	Comparison of decision rules	598	Three Wells and two Geneva	Composite imaging methods and independent adjudication committee	Sensitivity range 88–96% (simplified Wells); false negative range: 1.2% (simplified Wells) to 3.1%
Schouton 2014 [29]	PE	Prospective cohort/validation study	Diagnostic performance of decision rule in an elderly population	294c	Wells PE, and with age-related cut-offs [20]	Composite imaging methods + 3-month follow-up	29% and 24% ruled out using Wells and revised rule, respectively; false negative rate 5.9% and 2.9%, respectively

Bold type for authors of identified primary studies; remaining studies are based on data from primary study cohorts

It is important to note that all of the studies featured in this review employed the same qualitative lateral flow test, with a D-dimer cut-off value of 80 ng/mL

GP general practitioner

^aReference in brackets

^bNumber of patients where relevant data was available

^cParticipants resided in a nursing home setting