Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and fatal disease that is often delayed in its recognition or misdiagnosed.

This study reviewed the literature on diagnostic delay and its impact on patients and health systems.

Mean and median diagnostic delays were 6.1 and 3.4 years for ATTRwt-CM and 5.7 and 2.6 years for ATTRv-CM (weighted means of reported delays).

Patients reported evaluation by multiple healthcare providers before receiving a diagnosis of ATTR-CM, and incorrect or incomplete diagnoses were common.

Efforts are required to provide timely diagnosis so that patients can benefit from earlier access to new disease-modifying therapies.