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. 2021 May 17;11:9668. doi: 10.1038/s41598-021-88414-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Multi-modal imaging of ¹⁸F-FDG distribution in the A431 cell-derived tumor. (a) Illustration of tumor xenograft mouse. The arrow-head shows the location of the A431 cell-derived tumor. (b) Imaging to visualize tumor tissues using ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) coronal view image of the A431 xenograft SCID mouse. The arrow-head shows the A431 cell-derived tumor. (c) Macro-autoradiography of an A431 cell-derived tumor section. (d) Macro-autoradiography of diluted dosage. The spots show 1 μL of 1:200-, 1:400-, 1:800-, and 1:1600-diluted injected dosages, from right to left. (e) The tiling image of micro-autoradiographs of a whole section adjacent to (c) in dark field observation. (f) HE staining of an adjacent section of (c). Bars: 1000 μm.